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ORAU-managed beryllium lab marks outstanding year in 2013

Lab managed for DOE achieves zero error rate in beryllium lymphocyte proliferation test

April 3, 2014

ORAU Beryllium Testing Laboratory

ORAU-managed beryllium lab marks outstanding year in 2013 with zero test errors. Managed for DOE, lab personnel processed nearly 4,100 beryllium lymphocyte proliferation tests without a single error.

OAK RIDGE, Tenn.—For the second time in recent years, the Beryllium Testing Laboratory, managed by ORAU for the Department of Energy, performed flawlessly by processing nearly 4,100 beryllium lymphocyte proliferation tests (BeLPTs) in 2013, without a single error. The laboratory is one of only three laboratories in the U.S. that can perform the BeLPT.

The BeLPT is a blood test used to identify individuals at higher risk of developing Chronic Beryllium Disease, a chronic disease that scars the lungs making it more difficult for oxygen to transfer into the bloodstream. The test examines how a lymphocyte, which is a type of disease-fighting blood cell in a person’s body, reacts to beryllium and can determine if an individual is developing an immune response to beryllium.

Processing the blood for the test is a complex procedure that takes 10 to 14 days to complete and must follow a strict timeline to ensure accuracy in the results. Most of the procedure must be performed manually and must start within 24 to 30 hours of when the blood is drawn. To accommodate the national locations of patients, ORAU requires that each sample be shipped overnight to arrive in the lab the morning after it has been drawn. Once the sample is received, the actual test process begins first by using a centrifuge to separate lymphocytes from the blood sample. From there, numerous manual steps follow that include aspiration, washing and counting cells. The cell samples are then placed into different concentrations of beryllium and allowed to grow for five and seven days to determine the cells’ reaction when exposed to this chemical element.

Reliability in tests results is critical to workers wanting to know if they have developed sensitivity to beryllium and to managers who must make recommendations about whether active workers can still work with beryllium.

The ORAU-managed beryllium laboratory in Oak Ridge, Tenn., is certified under the Clinical Laboratory Improvement Act (CLIA) guidelines and has been awarded the prestigious College of American Pathologists (CAP) certification.

ORAU provides innovative scientific and technical solutions to advance national priorities in science, education, security and health. Through specialized teams of experts, unique laboratory capabilities and access to a consortium of more than 100 major Ph.D.-granting institutions, ORAU works with federal, state, local and commercial customers to advance national priorities and serve the public interest. A 501(c)(3) nonprofit corporation and federal contractor, ORAU manages the Oak Ridge Institute for Science and Education (ORISE) for the U.S. Department of Energy (DOE).

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