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The National Supplemental Screening Program (NSSP) is a health screening program for former U.S. Department of Energy workers.

In 1993, the U.S. Congress enacted Public Law 102-484, Section 3162 directing the U.S. Department of Energy to initiate a program to evaluate the health of former DOE workers who may have been exposed to hazardous substances at work. DOE, through its Office of Health, has sponsored beryllium screening for former workers from many sites; a surveillance program for Rocky Flats radiation workers; and several former worker, site-specific, health screening programs.

The newest initiative is called the National Supplemental Screening Program (NSSP). It is operated by Oak Ridge Associated Universities (ORAU) and its partners—National Jewish Health (NJH), Comprehensive Health Services Incorporated (CHS), Axion Health and the University of Colorado Denver. These organizations are highly respected for their expertise and capabilities in occupational medicine.